Interpol Inspector Zenigata embarks to Egypt in hot pursuit of world's most wanted master thief, Lupin the Third, who is seeking a stone artifact with his partners, Jigen and Goemon. Notorious femme fatale, Fujiko Mine is also after the stone, lured by the promise of eternal youth and beauty by the sinister and enigmatic scientist known as Mamo. It all leads to Mamo's hideaway, where Lupin discovers the madman's dark secret and a fiendish scheme that threatens the entire planet! Now, it's up to Lupin to stop the insane Mamo before he can complete his 10,000 year-old plans of world domination.